I upgraded both my iPhone 6 Plus and my iPad Air 2. The update killed all audio on my iPad. The speaker does nothing except an intermittent and random BZZT. With headphones, sound is incredibly distorted and totally unusable.
I had heard that custom ringtones had caused some issues on previous iOS updates, so I started playing around with it. I was able to solve my issues by doing a hard reset, then connect it to my rMBP and remove all ringtones via iTunes. Then another hard reboot. Sound came back. Re-synced my ringtones (all custom made that I've been using on all my devices since iPhone 3GS), and all is good again. It was a major annoyance, but fairly easy to resolve.