Like many here I set up two fingerprint profiles, one for my left thumb and one for my right thumb. The advantage is being able to unlock my iPhone with either hand. One thing that I did notice is that my grip made a big difference with how effective the reader was with each hand. So I created two more profiles one for my left thumb in a slightly different position and again for my right thumb. With four profiles programmed (2 for each thumb) I have noticed that my iPhone 5s is now working 100% of the time. Thought this may help those of you who are finding troubles with accessing your iPhone 5s based on grip.