Some initial thoughts, since I'm on the public beta. Battery life is awful for me but that's to be expected since it's a beta. No app issues with crashing so far which is good and all my apps that I need to work for work, actually work. Only real issue I noticed is trying to multitask with say gps and email I get some lag with the outlook email. I get some random screen jitters/scroll lag which never had before. Gboard is a bit funky and doesn't wanna work at times. Lastly one of my automations doesn't work but that's not a deal breaker. All of my other shortcuts and automations seem to work fine.
All of this could be due to the fact that I'm on a 12pro or just attributes to the beta process.
But really so far not bad!