I disabled the natural scrolling. While it makes complete sense, and I scroll that way every day with my iPhone...on my macbook it just feels weird! I'm sure I could get used to it, but for now I will stick with it off.
I much prefer the natural scrolling. It just makes more sense to me. Although I don't use a PC much anymore, when I do need to use one, it takes a bit to scroll the unnatural way.
I used a PC for about 20 years (yep I'm young), after getting my rMBP and going through settings I noticed the gesture section. There I learned about natural scrolling and all the fun of the gesture trackpad. Haven't looked back since. PC's without a mouse with a scroll wheel are painful to use now.