I would have to say there would be some concern and can't blame anyone like you for asking. If you have these doubts please call Otterbox CS/Support and see what they have to ssy. Best of luck.
i personally thought was to tight. i dunno im always paranoid about lint under it getting on screen so i keep a protector on phone under built in screen protector. the 3d touch thing still worked fine and all just seemed to tight. im to paranoid about damaging screen so i took it back.
I opted for a tempered glass screen protector and a Otterbox Commuter case for mine instead of the Defender with the built is plastic screen protector.
I have used one and had no issues. It was just too bulky for me so now I have a tempered glass and griffin survivor slim case. I have a feeling when my son starts soccer in the spring I will break out the Otterbox again.