When I can use it with more than one hand/thumb, I love the 6 plus. It's not too big for my pockets (I don't wear skinny pants but they are fitting) and I don't have any bend problems (with no case) but I also never put it in my back pocket. Most of the time I love the bigger screen, especially for reading (I also have an iPad mini that I still prefer to read on, but that's not ALWAYS with me like my iPhone is).
Unfortunately, there are enough situations where I have to use it with one hand/thumb and it's then that I'm reminded how frustrating that can be. Not just because I can't reach the top (if nothing else there's reach mode for that), but because I can't even reach the other side many times without tapping the wrong thing with my thumb or the pad between my thumb and my palm.
For this reason I'm thinking of switching to a 6s instead of a 6s Plus when they come out. I hate to do it because even the 6 feels too small after almost a year with the 6 plus, but I think I'd prefer some reachability (and less scare of dropping it when trying to reach) than the extra screen size. And hopefully I'll adjust my size perception to it like I did the 6 Plus.