Not really.
Had a Plus. Loved it for all the obvious reasons, and was annoyed by it for all the obvious reasons (size/handling). I love big screen phones, but the Plus was simply not practical for me for daily use. I absolutely need to be able to operate my phone one handed at work without any fuss. With the Plus I found myself putting it down and picking it back up a lot while I was working on what I was doing, whereas, with the 6, I can keep it in hand while doing other things with my hands. The 6 really is a perfect size for the hand, and it's designed that way as well in regards to button placement. The way-up-there position of the power button on the Plus is pretty silly.