You're IMO not clear enough, but yes anyone can create multiple calendars and sync them via iCloud; my devices sync two different accounts with a total of 10 calendars via iCloud, plus 3 via an Exchange account (a real Exchange account, not a Google EAS account), all simultaneously.
FWIW, and why I feel you aren't clear enough is that now we can create new iCloud calendars directly on our iOS 5 devices; I haven't checked whether we can create calendars on other server types.